Gịnị bụ Shikimic Acid?

Asịd Shikimic (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) bụ ihe sitere n'okike nke na-eme ka ihe dị ndụ pụta ìhè nke bụ ihe dị mkpa n'etiti biosynthesis nke lignin, amino acid aromatic (phenylalanine, tyrosine na tryptophan), yana ọtụtụ alkaloids osisi na nje bacteria.

A na-ejikarị Shikimic acid eme ihe dị ka ihe mmalite maka mmepụta ọgwụ nje oseltamivir (ọgwụ nje influenza H5N1 nke a na-eji agwọ ma gbochie ụdị nje influenza niile a maara). Akọpụtala na mmepụta nke (-)-zeylenone dabere na Shikimic Acid bụ ihe a na-ejikarị eme ihe dị ka ihe na-agwọ kansa chemotherapy. Enwere ike ịnweta data gbasara mmepụta nke monopalmitoyloxy Shikimic Acid, nke nwere ọrụ anticoagulant ma nwee ike ibelata coagulation ọbara mgbe a na-enye ya n'ime intramuscular. Otu ndị nyocha China mepụtara ihe sitere na Shikimic Acid, triacetyl Shikimic Acid, nke na-egosipụta ọrụ anticoagulant na antithrombotic.

Tinyere nke a, ihe ndị sitere na Shikimic Acid egosila nnukwu mmasị n'ọrụ ugbo ebe a na-eji ọtụtụ n'ime ha dị ka ọgwụ ogwu na ọgwụ nje n'ihi na ha nwere ike igbochi ụzọ Shikimic Acid n'ime osisi na nje bacteria na-enweghị mmetụta ọjọọ na anụmanụ.

Ya mere, enwere ike iji Shikimic Acid mee ihe dị ka ihe na-eme ka ihe ndị sitere n'okike dị na sayensị na ọgwụ dị iche iche, ọkachasị maka ịkwadebe ọgwụ dị iche iche.

Dịka ihe dị mkpa maka ọgwụ, a pụrụ iji shikimic acid gwọọ ọtụtụ ọrịa:

1. Ọgwụ nje na ọgwụ nje

Na 1987, ndị ọkà mmụta Japan chọpụtara na ihe analọg nke glyoxalase I inhibitor nke methyl anthranilate mepụtara nwere mmetụta mgbochi doro anya na mkpụrụ ndụ Hela na kansa Escheri ascites nwere ike ịgbatị oge ndụ nke òké ndị a gbara mkpụrụ ndụ leukemia L1210 ọgwụ, na nsí ahụ dị obere, mmetụta mgbochi ya na-emetụtakarị mmeghachi omume sulfur hydride. 1988, ndị ọkà mmụta China ekwuola na 1988, ndị ọkà mmụta China emepụtala ihe sitere na shikimic acid ma gosipụta na ihe mejupụtara a nwere mmetụta nke igbochi mkpụrụ ndụ leukemia L1210 na vitro.

2. Mgbochi thrombosis

Mmetụta nke shikimic acid na ihe ndị sitere na ya na sistemụ obi na-egosi ọrụ nke mgbochi thrombosis na igbochi nchịkọta platelet. Nnyocha na-egosi na: shikimic acid nwere mmetụta siri ike na ọnụego nchịkọta platelet nke adenosine diphosphate nke ụdị akara embolism nke etiti ụbụrụ na-akpata; ntinye shikimic acid n'ime akwara na intramuscular nwere ike ime ka oge mkpụkọ ọbara nke òké dị ogologo.

3. Mgbochi ọrịa ụbụrụ

Shikimic acid na ihe ndị sitere na ya nwere mmetụta nke ime ka ụbụrụ ghara ịdị mma, ọkachasị n'ibelata olu nke nkụchi obi mgbe ụbụrụ focal ischemia gasịrị n'ime oke, ibelata akara ọrụ akwara, ibelata ogo nke edema ụbụrụ, ịbawanye ọbara n'ime mpaghara ischemic na ihe ngosi ndị ọzọ. Ụfọdụ ọmụmụ egosila na ihe ndị sitere na ya nwere ike ibelata ogo nke nchịkọta erythrocyte ma gbochie nchịkọta platelet mgbe ụbụrụ adịghịzi, si otú a na-eme ka obere mgbanwe nke ụbụrụ dịkwuo mfe.