Kedu ihe bụ Shikimic acid?

Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) bụ ihe sitere n'okike nke bụ ihe dị mkpa na biosynthesis nke lignin, amino acid aromatic (phenylalanine, tyrosine na tryptophan), na ọtụtụ. osisi na microbial alkaloids.

A na-ejikarị Shikimic acid mee ihe dị ka ihe mmalite maka njikọ mmepụta ihe nke ọgwụ mgbochi nje oseltamivir (ọgwụ nje nje na-egbochi H5N1 nke a na-eji na-agwọ ma gbochie ụdị nje nje influenza niile mara). Ngwakọta nke (-) zeylenone dabere na Shikimic Acid ka akọpụtala ka ejiri ya mee ihe n'ọtụtụ ebe dị ka onye na-ahụ maka ọgwụgwọ ọrịa kansa. Data dị na njikọ nke monopalmitoyloxy Shikimic Acid, nke nwere ọrụ anticoagulant ma nwee ike ibelata coagulability ọbara mgbe a na-enye ya intramuscularly. Otu onye nyocha nke China rụpụtara ihe nrụpụta Shikimic Acid, triacetyl Shikimic Acid, nke na-egosipụta ọrụ anticoagulant na antithrombotic.

Tụkwasị na nke ahụ, ihe ndị na-emepụta Shikimic Acid egosila mmasị dị ukwuu na ọrụ ugbo n'ihi na a na-eji ọtụtụ n'ime ha eme ihe dị ka ahịhịa na ọgwụ nje n'ihi na ha nwere ike igbochi ụzọ Shikimic Acid na osisi na nje bacteria na-enweghị emetụta mammals na-adịghị mma.

Ya mere, enwere ike iji Shikimic acid mee ihe dị ka ihe na-emeghachi omume maka njikọ nke organic na sayensị sayensị na ngwa ahụike na kemịkalụ organic na ọgwụ, karịsịa maka nkwadebe ọgwụ dị iche iche.

Dị ka ihe dị mkpa ọgwụ kemịkal, shikimic acid nwere ike tinye n'ọrụ na ọgwụgwọ nke ọtụtụ ọrịa:

1. Antibacterial na antitumor

N'afọ 1987, ndị ọkà mmụta Japan chọpụtara na analog nke glioxalase I inhibitor nke methyl anthranilate mebere nwere mmetụta mgbochi doro anya na ahịrị Hela cell na Escheri ascites carcinoma, nwere ike ịgbatị oge ndụ ụmụ oke ejiri leukemia cell L1210, na nsị dị ntakịrị. Mmetụta mgbochi ya na-emetụtakarị mmeghachi omume sulfur hydride. 1988, ndị ọkà mmụta China nwere N'afọ 1988, ndị ọkà mmụta China emepụtala ihe na-emepụta shikimic acid ma gosipụta na ogige a nwere mmetụta nke igbochi leukemia cell L1210 in vitro.

2. Mgbochi thrombosis

A na-egosipụta mmetụta nke shikimic acid na ihe ndị na-emepụta ya na sistem obi na akwara na ọrụ mgbochi thrombosis na mgbochi nke nchịkọta platelet. Nnyocha na-egosi na: shikimic acid nwere mmetụta mgbochi siri ike na nchịkọta platelet nke adenosine diphosphate na-ebute etiti cerebral artery embolism ụdị oke; intravenous na intramuscular injection shikimic acid nwere ike ime ka oge mkpụkọ ọbara nke ụmụ oke dị ogologo.

3.Anti-cerebral ischemia

Shikimic acid na ihe ndị sitere na ya nwere mmetụta nke imeziwanye ischemia cerebral, tumadi n'ibelata olu nke infarction cerebral mgbe a na-ahụ maka ụbụrụ ụbụrụ ụbụrụ na oke, na-ebelata akara ọrụ akwara ozi, na-ebelata ogo nke ụbụrụ ụbụrụ, na-amụba ọbara ụbụrụ ụbụrụ na mpaghara ischemic. na ihe ngosi ndị ọzọ. Ụfọdụ ọmụmụ egosila na ihe ndị na-emepụta ya nwere ike ibelata ogo nchịkọta erythrocyte ma gbochie nchịkọta platelet mgbe ischemia ụbụrụ gasịrị, si otú a na-eme ka microcirculation ụbụrụ dị mma.