1. Endothelin antagonists

A na-ewepụta ya na chamomile nke Europe, nke nwere ike iguzogide endothelin ma gbochie mmepụta nke melanocytes.Nkesa na-ezighi ezi nke endothelin na akpụkpọ ahụ bụ isi ihe na-eduga n'ịmepụta pigmenti.Ndị na-emegide endothelin nwere ike igbochi endothelin.. tyrosinase ma kwalite ọdịiche nke melanocytes.

Nnyocha achọpụtala na ndị na-emegide endothelin nke a na-enweta site na ihe ndị dị ndụ na mmiri nwere obere cytotoxicity ma nwee ike igbochi ọdịiche nke endothelin na melanocytes na ọrụ tyrosinase.Ọrịa hyperpigmentation akpụkpọ ahụ kpatara mmụba -l nwere ike ịnwe atụmanya ngwa.

2. Resveratrol na mmepụta ya

Resveratroltumadi dị na mkpụrụ vaịn, Polygonum cuspidatum, Veratrum na osisi ndị ọzọ, ma na-egbochi ọrụ nke melanocytes na ọrụ tyrosinase n'ụzọ dabere na ntinye uche, si otú a na-ebelata njikọ nke melanin.Jeong et al chọpụtara na ọ na-ejikọta ya na protein ndị metụtara tyrosinase na melanogenesis.

Jia Lili na nchọpụta ndị ọzọ egosila na resveratrol topical nwere ike imeziwanye ụcha akpụkpọ ahụ nke ọma, nwere mmetụta na-acha ọcha, na enweghị mmeghachi omume ọjọọ.Resveratrol nwere ihe ọghọm nke enweghị ntụkwasị obi yana bioavailability adịghị mma.Nnyocha achọpụtala na usoro ya (pentaalkyl ether derivatives na tetraester derivatives) nwere nnukwu bioavailability ma nwee ike igbochi njikọ nke melanin nke ọma.Ọ nwere ohere sara mbara ngwa na-acha ọcha ịchọ mma.

3. Camellia wepụ

Camellia bụ ezinụlọ Camellia nke ezinụlọ Camellia.Nakamura et al.chọpụtara na mkpụrụ osisi camellia nwere ike igbochi mmepụta melanin ma kwalite ọdịiche nke fibroblast.Huang Xiaofeng na ndị ọzọ ọmụmụ kwubiri na Dianshan tii alaka na akwukwo wepụ dị mma karịa arbutin na okwu nke cell proliferation na mgbochi nke tyrosinase ọrụ, na nwere mma Njirimara karịa arbutin.Ọ bụ ụdị ọhụrụ nke na-eme ka akpụkpọ ahụ dị ọcha ma nwee ọtụtụ ngwa.atụmanya.

MelaninSynthaseIonye na-egbochi ihe

1. Arbutin

Ọ bụ ihe mgbochi tyrosinase dị mkpa, nke nwere ike igbochi ọrụ tyrosinase, gbochie njikọ nke dopa na dopaquinone, si otú a na-egbochi mmepụta nke melanin, ma nwee ike belata pigmenti nke ụzarị ultraviolet kpatara, mana ọ kwụsiri ike, na-arụ ọrụ adịghị mma, yana ụfọdụ. photosensitivity.

Nnyocha ahụ chọpụtara na arbutin nwere ntinye nke 3% nwere ezigbo ihe, cytotoxicity dị ala, mgbakasị ahụ na nfụkasị ahụ, na oke elu nke itinye uche ya enweghị ike ịgafe 7%.Nnukwu itinye uche nke arbutin ga-agbanwe akpụkpọ ahụ nkịtị.Ihe mejupụtara ya na-arụ ọrụ, glucopyranoside, nwere mmetụta mgbochi siri ike na tyrosinase mmadụ karịa arbutin, ma dochie arbutin n'ihi na ọ dị irè ma kwụsie ike.

2. Mwepụ licorice

Ihe na-arụ ọrụ ya bụ liquiritin, isoliquiritin na flavonoids licorice.Liquiritin na-eme ka melanin akpụkpọ ahụ kesaa nke ọma site n'ịgbasa melanin ekpokọtara, ma nweta mmetụta na-acha ọcha;Isi ọrụ nke licorice flavonoids bụ igbochi ọrụ tyrosinase, DHICA oxidase na dopa pigmenti intermutase.

Nnyocha achọpụtala na ngwaahịa nlekọta anụ ahụ nke nwere licorice wepụ na papain nwere ike inyere melasma na post-inflammatory hyperpigmentation, na-enwe obere mmeghachi omume ọjọọ, ma nwee ụfọdụ .. na .. Njirimara.Ntinye ya na ngwaahịa ndị na-acha ọcha bụ 10% ruo 40%, mana ọdịnaya nke ihe ndị na-arụ ọrụ na licorice adịghị elu ma dị ọcha siri ike ma dị oke ọnụ.

3. Chuanxiong wepụ

Nnyocha achọpụtala na Chuanxiong wepụ nwere ike igbochi ọrụ tyrosinase nke ọma, na-egosi mmetụta mgbochi asọmpi.Ude nke Chuanqiong mepụtara site na usoro ngwakọta nke emulsifiers dị iche iche na ndị dị iche iche dị iche iche, nyocha nke ịdị ọcha ya na arụmọrụ ya gosiri na 0.5% ~ 1.0% mmanụ aṅụ Chuanqiong nwere njirimara nke nkwụsi ike dị mma, arụmọrụ dị elu na ezigbo ịcha ọcha.

4. Rhodiola Rosea wepụ

Salidroside na flavonoids bụ ihe ndị bụ isi na-arụ ọrụ ya, na salidroside nwere ike imebi lipids na membranes cell site na ụzarị ultraviolet.Mwepụta ahụ nwere ike igbochi njikọ nke melanin na ọrụ tyrosinase, ma bụrụ ihe na-eme ka akpụkpọ anụ dị irè.Nnyocha ahụ chọpụtara na 1% na 5% nke Rhodiola rosea wepụ emeghị ka mmeghachi omume na-adịghị mma na ahụ mmadụ, na ọ bụ ihe ịchọ mma na-arụ ọrụ nke nwere nkwụsi ike dị elu ma nwee atụmanya sara mbara na ngwa ịchọ mma.

5. Aloin

Ọ bụ osisi glycoprotein dị arọ nke dị ala nke ewepụtara na aloe vera.Ọ na-egbochi nguzobe nke dopaquinone site na ịsọ mpi na-egbochi saịtị dopa oxidation, ma nweta ihe mgbochi na-abụghị asọmpi site na ịsọ mpi igbochi ion ọla kọpa na saịtị hydroxylase.Ọrụ nke tyrosine hydroxylase.Tụkwasị na nke ahụ, aloin nwekwara ike ibelata nhụsianya akpụkpọ ahụ nke ụzarị ultraviolet kpatara, na-enwekwa mmetụta dị mma na-arụzi akpụkpọ ahụ mgbe anwụ gachara.Aloin bụ hydrophilic na-abụghị cytotoxic.Ịgwakọta aloin na arbutin nwere ike melite mmetụta ịcha ọcha.

6. Polyphenols osisi

Ọ na-adịkarị na ogbugbo, mgbọrọgwụ, akwụkwọ na mkpụrụ osisi, yana mmetụta ya na-acha ọcha na-emetụta ya na mmịnye nke ụzarị ultraviolet, mkpochapụ antioxidant nke free radicals, na mgbochi nke tyrosinase na peroxidase ọrụ.Ellagic acid bụ polyphenol eke sitere na bee pọmigranet, ogbugbo na mkpụrụ osisi na akwụkwọ nri dị iche iche.Ọ nwere ike igbochi mgbasa nke melanocytes, gbochie ọrụ melanocyte tyrosinase, belata njikọ nke melanin, ụzarị ultraviolet nwere mmetụta mmịpụta siri ike, nke nwere ike ịrụ ọrụ na nchebe anyanwụ ma ọ bụ na-ekpochapụ radicals n'efu site n'inweta ụzarị ultraviolet.Osisi polyphenol bụ ụdị ihe dị irè, nke nwere atụmanya sara mbara maka mmepe na itinye n'ọrụ nke ịchọ mma.

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Ụlọ ọrụ Shaanxi Ruiwo Phytochem Co.,Ltd.
Onye njikwa mba ofesi: Jason
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Email:jason@ruiwophytochem.com
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