Anyị na-eji kuki eme ka ahụmịhe gị ka mma. Site n'ịga n'ihu na-achọgharị na saịtị a, ị kwenyere na anyị na-eji kuki. Ozi ndị ọzọ.
Site na ịpị "Kwe Ka Ihe Niile" , ị kwenyere na ị ga-echekwa kuki na ngwaọrụ gị iji mee ka ọ dịkwuo mma ịnyagharịa saịtị, nyochaa ojiji saịtị, ma kwado inye anyị ọdịnaya sayensị n'efu, nke mepere emepe. Ozi ndị ọzọ.
N'ọmụmụ ihe e bipụtara n'akwụkwọ akụkọ Pharmaceutics n'oge na-adịbeghị anya, ndị nchọpụta chọpụtara na ọgwụ nje nke a na-akpọ FRO na-alụso ọrịa akpụkpọ ahụ ọgụ na-arụ ọrụ nke ọma.
Nnyocha ọgwụ nje na nyocha in vitro gosiri na FRO nwere mmetụta dị ukwuu nke nje bacteria na mgbochi mbufụt megide Dermatobacillus Acnes (CA), nje bacteria nke na-akpata ihe otutu. Nsonaazụ ndị a na-egosi ojiji ya dị mma na nke eke n'ịgwọ ihe otutu, na-akwado ojiji nke ihe ndị ọzọ na-adịghị egbu egbu na ndị dị ọnụ ala karịa ọgwụ ihe otutu ugbu a.
Ọmụmụ ihe: Mmetụta nke FRO na ọrịa acne vulgaris. Ebe e si nweta foto: Steve Jungs/Shutterstock.com
Akpịrị vulgaris, nke a na-akpọkarị pimples, bụ ọrịa akpụkpọ ahụ a na-ahụkarị site na follicles ntutu kpọchiri akpọchi nke nwere sebum na sel akpụkpọ ahụ nwụrụ anwụ. Akpịrị na-emetụta ihe karịrị pasentị iri asatọ nke ndị ntorobịa, ọ bụ ezie na ọ bụghị ọnwụ, ọ nwere ike ibute nsogbu uche, ma n'ọnọdụ ndị siri ike, agba akpụkpọ ahụ na ọnya na-adịgide adịgide.
Ihe otutu na-esi na mmekọrịta nke ihe ndị sitere na mkpụrụ ndụ ihe nketa na gburugburu ebe obibi pụta, nke a na-enwekarị site na mgbanwe homonụ nke na-eso oge ntozu okè. Enweghị nhazi homonụ ndị a na-eme ka mmepụta sebum dịkwuo elu ma na-eme ka ọrụ insulin growth factor 1 (IGF-1) na dihydrotestosterone (DHT) dịkwuo elu.
A na-ewere mmụba nke sebum dị ka ọkwa mbụ n'ime mmepe nke ihe otutu, ebe ọ bụ na follicles ntutu jupụtara na sebum nwere ọtụtụ nje dị iche iche dịka SA. SA bụ ihe sitere n'okike nke akpụkpọ ahụ; agbanyeghị, mmụba nke phylotype IA1 ya na-akpata mbufụt na agba nke follicles ntutu nwere papules a na-ahụ anya n'èzí.
E nwere ọtụtụ ọgwụgwọ ịchọ mma maka ihe otutu, dịka retinoids na ihe ndị na-akpata nje bacteria n'ahụ, nke a na-eji ya na akpụkpọ kemịkalụ, ọgwụgwọ laser/light, na ihe ndị na-akpata homonụ. Agbanyeghị, ọgwụgwọ ndị a dị oke ọnụ ma nwee mmetụta ọjọọ.
Nnyocha ndị gara aga enyochala ihe ndị sitere n'okike dị ka ihe ọzọ dị ọnụ ala maka ọgwụgwọ ndị a. Dịka ihe ọzọ, amụọla ihe ndị sitere n'okike Rhus vulgaris (RV). Agbanyeghị, urushiol, otu n'ime ihe ndị na-akpata nfụkasị osisi a, ejiri ya belata ojiji ya.
FRO bụ usoro ọgwụ nwere ihe ndị e ji amịpụta RV (FRV) na mangosteen Japanese (OJ) n'ime oke 1:1. A nwalela irè nke usoro ahụ site na iji in vitro na ihe ndị na-egbochi nje.
E bu ụzọ mata ngwakọta FRO site na iji high performance liquid chromatography (HPLC) iji kewapụ, chọpụta ma tụọ ihe mejupụtara ya. E nyochakwara ngwakọta ahụ maka ọdịnaya phenolic zuru oke (TPC) iji chọpụta ihe ndị nwere ike ịnwe ihe ndị na-egbu nje.
Nnyocha nje bacteria mbụ site n'inyocha mmetụta mgbasa diski. Nke mbụ, e ji otu ihe kụọ CA (phylotype IA1) n'elu efere agar nke e tinyere diski akwụkwọ nzacha FRO nke dị mm 10 n'obosara. E lere ọrụ nje bacteria anya site n'ịtụ nha mpaghara mgbochi ahụ.
E jiri nyocha Oil Red staining na Western blot nyochaa irè nke FRO na mmepụta sebum nke CA kpatara na androgen surges nke DHT. E mesịa nwalee FRO maka ikike ya iji belata mmetụta nke ụdị oxygen reactive (ROS), bụ ndị na-akpata hyperpigmentation metụtara ihe otutu na ọnya mgbe ịwa ahụ gasịrị, site na iji nyocha 2′, 7′-dichlorofluorescein diacetate (DCF-DA). kpatara ya.
Nsonaazụ nke nnwale mgbasa diski gosiri na 20 μL nke FRO gbochiri uto CA nke ọma ma mepụta mpaghara mgbochi doro anya nke 13 mm na mkpokọta nke 100 mg/mL. FRO na-egbochi mmụba nke sebum nke SA kpatara nke ukwuu, si otú a na-ebelata ma ọ bụ na-agbanwe ihe otutu.
A chọpụtala na FRO bara ụba na ihe ndị dị ka gallic acid, kaempferol, quercetin na fisetin. Ngụkọta ihe mejupụtara phenolic (TPC) nkezi bụ 118.2 mg nke ihe mejupụtara gallic acid (GAE) kwa gram FRO.
FRO belatara mbufụt nke mkpụrụ ndụ nke sitere na mwepụta nke SA kpatara ROS na cytokine. Mbelata ogologo oge na mmepụta ROS nwere ike ibelata ọbara ọbara na ọnya.
Ọ bụ ezie na ọgwụgwọ akpụkpọ ahụ maka ihe otutu dị, ha na-adịkarị oke ọnụ ma nwee ike inwe ọtụtụ mmetụta ọjọọ a na-achọghị.
Nsonaazụ ya gosiri na FRO nwere ihe ndị na-egbu nje bacteria megide CA (nje bacteria na-akpata ihe otutu), si otú a na-egosi na FRO bụ ihe e kere eke, nke na-adịghị egbu egbu ma dịkwa ọnụ ala karịa ọgwụgwọ ihe otutu ọdịnala. FRO na-ebelatakwa mmepụta sebum na mmepụta homonụ n'ime vitro, na-egosi irè ya n'ịgwọ na igbochi ihe otutu.
Nnwale ahụike FRO gara aga gosiri na ndị na-eji toner na ude FRO dị elu enwetala mmụba dị ukwuu na njupụta akpụkpọ ahụ na ọkwa mmiri ma e jiri ya tụnyere ndị otu njikwa mgbe naanị izu isii gachara. Ọ bụ ezie na ọmụmụ ihe a enyochaghị ihe otutu n'okpuru ọnọdụ in vitro achịkwa, nsonaazụ dị ugbu a na-akwado nchọpụta ha.
N'ịchịkọta ihe ndị a, nsonaazụ ha na-akwado ojiji FRO n'ọdịnihu n'ọgwụgwọ ịchọ mma, gụnyere ọgwụgwọ ihe otutu na ime ka ahụike akpụkpọ ahụ ka mma.
E deziri akụkọ a na Juun 9, 2023 iji dochie foto bụ isi na nke kwesịrị ekwesị.
E tinyere na: Akụkọ Sayensị Ahụike | Akụkọ Nnyocha Ahụike | Akụkọ Ọrịa | Akụkọ Ọgwụ
Tags: ihe otutu, ndị nọ n'afọ iri na ụma, androgens, mgbochi mkpali, mkpụrụ ndụ, chromatography, cytokines, dihydrotestosterone, irè, ịgbaze, mkpụrụ ndụ ihe nketa, ihe ndị na-eto eto, ntutu isi, homonụ, hyperpigmentation, in vitro, mbufụt, insulin, phototherapy, mmiri mmiri chromatography, oxygen, mmụba, quercetin, retinoids, akpụkpọ ahụ, mkpụrụ ndụ akpụkpọ ahụ, agba akpụkpọ ahụ, Western blot
Hugo Francisco de Souza bụ onye edemede sayensị nke bi na Bangalore, Karnataka, India. Ihe gbasara agụmakwụkwọ ya dị na ngalaba bayọlọji, bayoloji evolushọn na herpetology. Ọ na-arụ ọrụ ugbu a na edemede doctorate ya. site na Center for Environmental Sciences na Indian Institute of Science, ebe ọ na-amụ mmalite, nkesa na ụdị agwọ mmiri mmiri. E nyere Hugo onyinye DST-INSPIRE Fellowship maka nyocha doctorate ya na ihe nrite ọlaedo site na Mahadum Pondicherry maka ihe ndị o rụzuru n'agụmakwụkwọ ya n'oge ọmụmụ Master ya. E bipụtala nnyocha ya na akwụkwọ akụkọ ndị ọgbọ nyochara nke ukwuu gụnyere PLOS Neglected Tropical Diseases and Systems Biology. Mgbe ọ naghị arụ ọrụ ma na-ede ihe, Hugo na-agụ ọtụtụ anime na ihe ọchị, na-ede ma na-ede egwu na bass guitar, na-akụ egwu na MTB, na-egwu egwuregwu vidiyo (ọ na-ahọrọ okwu ahụ bụ "egwuregwu"), ma ọ bụ na-akụ ihe na ihe fọrọ nke nta ka ọ bụrụ teknụzụ.
Francisco de Souza, Hugo. (Julaị 9, 2023). Ngwakọta pụrụ iche nke ihe ndị sitere na osisi na-enye uru dị ike maka mgbochi ihe otutu. Akụkọ - Ahụike. E wetara ya na Septemba 11, 2023, site na https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Francisco de Souza, Hugo. “Ngwakọta pụrụ iche nke ihe ndị sitere n'osisi nwere ihe ndị dị ike na-egbochi ihe otutu.” Akụkọ – Ahụike. Septemba 11, 2023.
Francisco de Souza, Hugo. “Ngwakọta pụrụ iche nke ihe ndị sitere n'osisi nwere ihe ndị dị ike na-egbochi ihe otutu.” Akụkọ – Ahụike. https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx. (E nwetara ya na Septemba 11, 2023).
Francisco de Souza, Hugo. 2023. Ngwakọta pụrụ iche nke ihe ndị sitere n'osisi nwere ihe ndị dị ike na-egbochi ihe otutu. News Medical, enwetara na Septemba 11, 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Foto ndị e ji mee ihe na "nchịkọta" a ejikọtaghị na nnyocha a ma ha na-eduhie eduhie kpamkpam n'ikwu na nnyocha ahụ gụnyere nnwale n'ahụ mmadụ. E kwesịrị iwepụ ya ozugbo.
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N'ihe nkiri ọhụrụ a, Keith Stumpo nke Bruker na-akọwa ohere dị iche iche nke ngwaahịa eke na Pelle Simpson nke Enveda.
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