Anyị na-eji kuki iji kwalite ahụmịhe gị. Site n'ịga n'ihu na-achọgharị saịtị a, ị kwenyere na ojiji anyị ji kuki. Ozi ndị ọzọ.
Site na ịpị “Kwe Ka Ihe Nile”, ị kwenyere na ị na-echekwa kuki na ngwaọrụ gị iji welie igodo saịtị, nyochaa ojiji saịtị, ma kwado ịnye ọdịnaya sayensị ohere mepere emepe n'efu. Ozi ndị ọzọ.
N'ime nnyocha e bipụtara n'oge na-adịbeghị anya n'akwụkwọ akụkọ Pharmaceutics, ndị nchọpụta kpebiri irè antimicrobial nke usoro ogwu a na-akpọ FRO megide acne pathogenesis.
Ntụle ọgwụ mgbochi na nyocha in vitro gosiri na FRO nwere mmetụta antibacterial na mgbochi mkpali megide Dermatobacillus Acnes (CA), nje na-akpata ihe otutu. Nsonaazụ ndị a na-egosiputa ojiji nchekwa ya na nke okike na ọgwụgwọ ịchọ mma nke ihe otutu, na-akwado iji ihe ndị ọzọ na-adịghị egbu egbu na ọnụ ahịa dị mma maka ọgwụ ihe otutu ugbu a.
Ọmụmụ: Ịrụ ọrụ FRO na pathogenesis nke acne vulgaris. Ebe e si nweta foto: Steve Jungs/Shutterstock.com
Acne vulgaris, nke a na-akpọkarị pimples, bụ ọnọdụ akpụkpọ ahụ nke na-akpata site na ntutu isi kpuchiri ya na sebum na mkpụrụ ndụ nwụrụ anwụ. Ihe otutu na-emetụta ihe karịrị pasenti 80 nke ndị nọ n'afọ iri na ụma na, ọ bụ ezie na ọ bụghị ihe na-egbu egbu, nwere ike ịkpata nsogbu uche na, n'ọnọdụ siri ike, pigmenti anụ ahụ na-adịgide adịgide na ọnya.
Ihe otutu na-esite na mmekọrịta nke mkpụrụ ndụ ihe nketa na gburugburu ebe obibi, nke na-ebutekarị site na mgbanwe hormonal na-eso ntolite n'oge uto. Mgbanwe nke hormonal ndị a na-abawanye mmepụta sebum ma na-abawanye mmepụta insulin 1 (IGF-1) na ọrụ dihydrotestosterone (DHT).
A na-ewere mmụba nke sebum dị ka ọkwa mbụ na mmepe nke ihe otutu, ebe ọ bụ na ntutu isi jupụtara na sebum nwere ọnụ ọgụgụ dị ukwuu nke microorganisms dị ka SA. SA bụ ihe sitere n'okike nke anụ ahụ; Otú ọ dị, ịba ụba nke phylotype IA1 ya na-akpata mbufụt na pigmentation nke ntutu isi na papules a na-ahụ anya.
Enwere ọgwụgwọ ịchọ mma dị iche iche maka ihe otutu, dị ka retinoids na ihe ndị na-ahụ maka microbial, ejiri ya na peels kemịkalụ, ọgwụgwọ laser / ìhè, na ndị na-ahụ maka hormonal. Agbanyeghị, ọgwụgwọ ndị a dị oke ọnụ ma jikọtara ya na mmetụta ọjọọ.
Ọmụmụ ihe ọmụmụ gara aga enyochala mịpụta ahịhịa dị ka ụzọ dị mma maka ọgwụgwọ ndị a dị ọnụ ahịa. Dị ka ihe ọzọ, a mụọla mpụta Rhus vulgaris (RV). Otú ọ dị, urushiol, bụ isi ihe na-eme ihe nfụkasị ahụ nke osisi a kpaara iji ya mee ihe.
FRO bụ usoro ahịhịa nwere mịpụta fermented nke RV (FRV) na mangosteen Japanese (OJ) na nha 1:1. A nwalela ịdị irè nke usoro a site na iji nyocha in vitro na ihe ndị na-egbochi nje.
Ebu ụzọ mara ngwakọta FRO site na iji chromatography mmiri dị elu (HPLC) iji kewapụ, chọpụta na tụọ akụkụ ya. A tụlekwara ngwakọta a maka mkpokọta phenolic ọdịnaya (TPC) iji chọpụta ogige ndị nwere ike ịnwe ihe mgbochi.
Nnwale mgbochi mgbochi in vitro nke mbido site n'ịtụle nghọta mgbasa nke diski. Nke mbu, CA (phylotype IA1) ka edobere n'otu n'otu n'efere agar nke etinyere dayameta 10mm FRO-impregnated FRO disk disk. A na-enyocha ọrụ mgbochi ọrịa site na ịlele nha mpaghara mgbochi ahụ.
A na-enyocha ịdị irè nke FRO na mmepụta sebum nke CA na-akpata yana DHT jikọtara ya na androgen surges site na iji mmanụ uhie na nyocha nke Western blot, otu. Emechara nwale FRO maka ike ya iwepụ mmetụta nke ụdị oxygen na-emeghachi omume (ROS), bụ ndị na-ahụ maka hyperpigmentation metụtara otutu na ọnya mgbe ịwachara ahụ, na-eji nyocha 2′,7′-dichlorofluorescein diacetate (DCF-DA). kpatara.
Nsonaazụ nke nnwale mgbasa ozi diski gosiri na 20 μL nke FRO gbochiri uto CA nke ọma wee mepụta mpaghara mgbochi pụtara ìhè nke 13 mm na ntinye nke 100 mg/mL. FRO na-ebelata nke ọma mmụba nke sebum secretion nke SA na-akpata, si otú a na-ebelata ma ọ bụ na-atụgharị ihe omume otutu.
Achọpụtala FRO bara ụba na ogige phenolic gụnyere gallic acid, kaempferol, quercetin na fisetin. Ngụkọta mkpokọta phenolic (TPC) ruru 118.2 mg galic acid dakọtara (GAE) kwa gram FRO.
FRO belatara mbufụt cellular nke SA na-ebute ROS na mwepụta cytokine. Mbelata ogologo oge na mmepụta ROS nwere ike ibelata hyperpigmentation na scarring.
Ọ bụ ezie na ọgwụgwọ dermatological maka ihe otutu dị, ha na-adịkarị ọnụ ma nwee ike inwe ọtụtụ mmetụta ndị achọghị.
Nsonaazụ gosiri na FRO nwere ihe ndị na-egbu nje megide CA (bacteria na-akpata ihe otutu), si otú ahụ na-egosi na FRO bụ ihe e kere eke, nke na-adịghị egbu egbu na nke na-efu ọnụ maka ọgwụgwọ ihe otutu omenala. FRO na-ebelata mmepụta sebum na okwu homonụ na vitro, na-egosipụta ịdị irè ya n'ịgwọ na igbochi ihe otutu.
Nnwale ụlọ ọgwụ FRO gara aga gosiri na ndị mmadụ na-eji toner na ude dị elu nke FRO nwetara mmụba dị ukwuu na nrịcha anụ ahụ na oke mmiri ma e jiri ya tụnyere ndị na-ahụ maka njikwa ka naanị izu isii gachara. Ọ bụ ezie na ọmụmụ ihe a enyochaghị ihe otutu n'okpuru ọnọdụ vitro na-achịkwa, ihe ndị dị ugbu a na-akwado nchọpụta ha.
N'ịchịkọta ọnụ, nsonaazụ ndị a na-akwado iji FRO n'ọdịnihu na ọgwụgwọ ịchọ mma, gụnyere ọgwụgwọ ihe otutu na ime ka ahụike akpụkpọ ahụ dịkwuo mma.
Edeziri akụkọ a na June 9, 2023 iji jiri nke dabara adaba dochie isi onyonyo a.
Ebiputere na: Akụkọ sayensị ahụike | Akụkọ nyocha ahụike | Akụkọ Ọrịa | Akụkọ gbasara ọgwụ
Tags: ihe otutu, na-eto eto, androgens, mgbochi mkpali, mkpụrụ ndụ, chromatography, cytokines, dihydrotestosterone, irè, gbaa ụka, mkpụrụ ndụ ihe nketa, ihe na-eto eto, ntutu isi, homonụ, hyperpigmentation, in vitro, mbufụt, insulin, phototherapy, chromatography mmiri, oxygen, proliferation. , quercetin , retinoids, akpụkpọ ahụ, mkpụrụ ndụ akpụkpọ anụ, pigmentation akpụkpọ, Western blot
Hugo Francisco de Souza bụ onye odee sayensị dabere na Bangalore, Karnataka, India. Mmasị agụmakwụkwọ ya dị na ngalaba biogeography, bayoloji evolushọn na herpetology. Ọ na-arụ ọrụ ugbu a na nzere doctoral ya. site na Center for Environmental Sciences na Indian Institute of Science, ebe ọ na-amụ mmalite, nkesa na nkọwa nke agwọ mmiri mmiri. Enyere Hugo onyinye DST-INSPIRE maka nyocha doctoral ya na ihe nrite ọla edo sitere na Mahadum Pondicherry maka mmezu agụmakwụkwọ ya n'oge ọmụmụ Master ya. Ebipụtala nyocha ya na akwụkwọ akụkọ nyocha ndị ọgbọ nwere mmetụta dị elu gụnyere PLOS Neglected Tropical Diseases and Systems Biology. Mgbe ọ naghị arụ ọrụ ma na-ede ihe, Hugo na-amanye ọtụtụ ihe nkiri na ihe nkiri, na-ede ma na-ede egwu na guitar bass, na-akụ egwu na MTB, na-egwu egwuregwu vidio (ọ masịrị okwu ahụ bụ "egwuregwu"), ma ọ bụ ihe ọ bụla na-eme ka ọ bụrụ ihe ọ bụla. . teknụzụ.
Francisco de Souza, Hugo. (Julaị 9, 2023). Ngwakọta pụrụ iche nke mpụta ihe ọkụkụ na-enye uru dị ike na-egbochi ihe otutu. Akụkọ – Ọgwụ. Eweghachitere Septemba 11, 2023, site na https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Francisco de Souza, Hugo. "Ngwakọta pụrụ iche nke ihe ọkụkụ nwere ihe na-egbochi ihe otutu." Akụkọ – Ọgwụ. Septemba 11, 2023 .
Francisco de Souza, Hugo. "Ngwakọta pụrụ iche nke ihe ọkụkụ nwere ihe na-egbochi ihe otutu." Akụkọ – Ọgwụ. https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx. (Nwetara Septemba 11, 2023).
Francisco de Souza, Hugo. 2023. Ngwakọta pụrụ iche nke ihe ọkụkụ na-emepụta ihe na-emepụta ihe dị ike na-egbochi ihe otutu. Medical News, enwetara Septemba 11, 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Foto ndị e ji mee ihe na "nchịkọta" a enweghị ihe jikọrọ ya na ọmụmụ ihe a ma bụrụkwa ihe na-eduhie kpamkpam n'igosi na ọmụmụ ihe ahụ gụnyere ịnwale ụmụ mmadụ. Ekwesịrị iwepụ ya ozugbo.
N'ajụjụ ọnụ e mere na ogbako SLAS EU 2023 na Brussels, Belgium, anyị na Silvio Di Castro kwurịtara banyere nyocha ya na ọrụ nke njikwa ihe na nyocha ọgwụ.
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