Ọrịa cancer akpa ume bụ ụdị ọrịa kansa nke abụọ a na-ahụkarị n'ụwa. Na 2020, ihe karịrị nde mmadụ 2.2 n'ụwa niile ga-achọpụta ọrịa kansa akpa ume na nke mbụ. N'otu afọ ahụ, ihe dị ka nde mmadụ 1.8 n'ụwa niile nwụrụ n'ihi ọrịa kansa akpa ume.
Ọ bụ ezie na enweghị ọgwụgwọ maka ọrịa cancer akpa ume ugbu a, ndị ọkà mmụta sayensị na-arụ ọrụ na nhọrọ ọgwụgwọ. Ụfọdụ ndị ọkà mmụta sayensị a na-arụ ọrụ na Mahadum Teknụzụ Sydney (UTS), bụ ebe nchọpụta ọhụrụ gosiri na ihe ọkụkụ sitere n'okike nke a na-akpọ berberine nwere ike ịkwụsị uto mkpụrụ ndụ cancer akpa ume na ụlọ nyocha.
Berberine bụ ogige osisi sitere n'okike nke ejirila na ọgwụ ọdịnala ndị China kemgbe ọtụtụ puku afọ. A na-achọta ya n'ụdị osisi dị iche iche, gụnyere barberry, goldenseal, Oregon grape, na osisi turmeric.

(ngwaahịa anyị bụMkpụrụ osisi berberine, ezi obi nabata ase.)

Ọtụtụ afọ nyocha egosila na berberine dị irè n'inyere ndị nwere ụdị ọrịa shuga 2 aka ịhazi ọkwa shuga dị n'ọbara ha ma nwee ike inye aka na-agwọ ọrịa metabolic syndrome.
Ndị nchọpụta achọpụtakwala na a pụrụ iji berberine gwọọ ọrịa cancer dịgasị iche iche, gụnyere ọrịa ovarian, afọ, na ọrịa ara ara.
Dị ka Dr. Kamal Dua si kwuo, Onye isi nkuzi na onye ọkachamara nyocha na ụlọ ahịa ọgwụ na Australian Research Center for Complementary and Integrative Medicine (ARCCIM), University of Technology Sydney (UTS) School of Medicine na onye na-edu ndú nke ọmụmụ ihe, Berberine na-egbochi igodo abụọ. usoro na mmepe nke ọrịa cancer - Mgbasa na mbugharị cell.
"N'iji igwe, enwere ike nweta nke a site na igbochi mkpụrụ ndụ ihe nketa dị ka P53, PTEN na KRT18 na protein dị ka AXL, CA9, ENO2, HER1, HER2, HER3, PRGN, PDGF-AA, DKK1, CTSB, CTSD, BCLX, CSF1. na CAPG jikọtara ya na mmụba na mbugharị nke mkpụrụ ndụ kansa, "ka ọ kọwara.
N'ime ọmụmụ ihe ugbu a, otu ndị nchọpụta gụnyere Dr. Dua, Dr. Keshav Raj Paudel, Prọfesọ Philip M. Hansbrough na Dr. Bikash Manandhar nke UTS, yana ndị ọrụ si Malaysian International Medical University na Al Qasim University na Saudi Arabia. mụọ otú e nwere ike isi jiri berberine agwọ ọrịa cancer akpa ume.
"Ojiji ụlọ ọgwụ nke berberine nwere oke n'ihi adịghị ike solubility ya na bioavailability ya," Dr. Dua maka MNT kọwara. "Ebumnuche bụ isi nke ọmụmụ a bụ imeziwanye usoro physicochemical nke berberine site n'ịtụgharị berberine n'ime mmiri kristal nanoparticles na inyocha ike ya anticancer in vitro na alveolar epithelial basal cell nke mmadụ adenocarcinoma A549."
Ndị otu nyocha ahụ ewepụtala usoro nnyefe ọgwụ dị elu nke na-etinye berberine n'obere akụkụ soluble na ihe ndị na-emebi emebi. Ejila nanoparticles kristal mmiri mmiri na-agwọ mkpụrụ ndụ kansa akpa ume mmadụ na vitro n'ime ụlọ nyocha.
Na njedebe nke ọmụmụ ihe ahụ, otu ahụ chọpụtara na berberine nyere aka igbochi mmepụta nke ụdị oxygen na-emeghachi omume, kemịkalụ na-egbuke egbuke nke mkpụrụ ndụ ụfọdụ na-emepụta na nzaghachi maka mbuso agha nje na ihe omume ndị ọzọ na-akpata nchekasị nke nwere ike imebi mkpụrụ ndụ.
Na mgbakwunye, berberine na-enyere aka ịhazi mkpụrụ ndụ ihe nketa metụtara nrụgide oxidative na mbufụt, ma na-enyere aka belata ịka nká cell.
"Anyị egosila na, n'iji usoro nanotechnological mee ihe, ihe onwunwe nke ogige ahụ nwere ike imeziwanye ihe dị iche iche nke metụtara solubility, ntinye cellular, na ọgwụgwọ ọgwụgwọ," ka Dr. Dua kọwara. Nwere ike Anticancer Anyị mmiri kristal nanoparticles berberine gosipụtara otu ọrụ ahụ n'ime okpukpu ise karịa nke akwụkwọ e bipụtara, na-egosi nke ọma uru nke nanodrugs.
Iji nwalee nsonaazụ ndị a ọzọ, Dr. Dua kwuru na ya na-ezube iji usoro nyocha ọhụrụ ahụ na-eduzi ọmụmụ ihe omimi site na iji ụdị anụmanụ preclinical nke ọrịa cancer akpa ume.
"Ọmụmụ ọgwụ ndị ọzọ na ọgwụ mgbochi ọrịa nke berberine nanodrugs na ụdị anụmanụ na vivo nwere ike ikpughe uru ha nwere na ọgwụgwọ ọrịa cancer akpa ume ma mee ka ha ghọọ usoro ọgwụgwọ ọgwụgwọ," ka ọ kọwara.
"Ozugbo anyị kwadoro ikike mgbochi ọrịa cancer nke berberine nanodrugs na ụdị anụ ọhịa nke mbụ, nzọụkwụ ọzọ ga-abụ ịkwaga na ule ụlọ ọgwụ, nke anyị na-enweworị mkparịta ụka na ọtụtụ ụlọ ọrụ Sydney," ka Dr. Dua kwuru.
Tụkwasị na nke ahụ, Dr. Dua kwuru na ikike nke berberine iji gbochie nlọghachi nke ọrịa cancer akpa ume kwesịrị ikwenye: "Ọ bụ ezie na anyị enyochabeghị nke a, anyị na-eme atụmatụ ịmụ ya na ọmụmụ ihe n'ọdịnihu, anyị kwenyekwara na berberine nanoforms ga-egosi. ọrụ na-ekwe nkwa. ".
Dr. Osita Onuga, dọkịta na-awa ahụ thoracic na osote prọfesọ nke ịwa ahụ thoracic na St. John Cancer Institute na Providence St. John Medical Center na Santa Monica, California, gwara MNT na mgbe ndị nchọpụta chọtara ohere ọhụrụ iji gwọọ na igbochi ọrịa cancer, a na-enwe mgbe niile. olile anya:
"Berberine bụ akụkụ nke ọgwụ ndị dị n'Ebe Ọwụwa Anyanwụ, n'ihi ya, anyị adịghị eji ya eme ihe na nkà mmụta ọgwụ Western. Echere m na ọ bụ ihe na-adọrọ mmasị n'ihi na anyị na-ele anya na ihe anyị maara nwere ụfọdụ uru maka ọgwụ ndị dị n'Ebe Ọwụwa Anyanwụ, ma tinye ya na nyocha iji nyere aka sụgharịa ya na nkà mmụta ọgwụ Western. ".
Onuga gara n'ihu ikwu, "Ọ na-ekwe nkwa mgbe niile, mana ọ dị na ụlọ nyocha, na ọtụtụ ihe anyị na-ahụ n'ụlọ nyocha ahụ apụtaghị na a na-agwọ ndị ọrịa." "Echere m na ihe ọzọ ị ga-eme bụ ime ụfọdụ ule ụlọ ọgwụ na ndị ọrịa ma chọpụta usoro ọgwụgwọ."
Ụfọdụ ndị mmadụ na-enweta mgbaàmà dị nro nke ọrịa cancer akpa ume na mmalite nke ọrịa ahụ. Gụkwuo ka ịmụtakwu ihe, gụnyere mgbe ị ga-ahụ dọkịta.
Ọrịa cancer akpa ume na-apụta n'ụdị dị iche iche na ụmụ nwanyị na ụmụ nwoke, mana ihe mgbaàmà na ihe ndị dị ize ndụ bụ otu. N'ebe a, anyị na-akọwapụta mkpụrụ ndụ ihe nketa na hormonal…
Anyị bụ ndị ọkachamara na-emepụta ihe ọkụkụ na-emepụta ntụ ntụ, nabata iziga gị ajụjụ ọ bụla gbasara ngwaahịa anyị ma anyị nwere onye ọrụ ọrụ iji dozie nsogbu gị gbasara ire ere na mgbe ire ere. Kpọtụrụ anyị oge ọ bụla!!!