RutinUsoro kemịkal bụ (C27H30O16 • 3H2O), vitamin, nwere mmetụta nke ibelata permeability capillary na brittleness, na-echekwa ma weghachi elasticity nkịtị nke capillaries. Maka mgbochi na ọgwụgwọ hypertensive cerebral hemorrhage; A na-ejikwa ọbara ọgbụgba retina nke ọrịa mamịrị na hemorrhagic purpura dị ka antioxidants nri na pigmenti.

E kewara ya na njirisi anọ ndị a:

1. Rutin NF11: odo-acha akwụkwọ ndụ ntụ ntụ, ma ọ bụ ezigbo kristal acicular; Enweghị isi, enweghị ụtọ; Agba agba ọchịchịrị na ikuku; Na-ekpo ọkụ na 185-192 ℃, ọ na-aghọ a aja aja gelatinous ahu na decomposes na banyere 215 ℃. Obere soluble na ethanol na-esi esi, na-agbaze ntakịrị na mmiri esi mmiri, dị ntakịrị soluble na mmiri oyi, ọ dị mfe soluble na mmanya isopropyl na methanol, na-adịghị ike na trichloromethane, ether na benzene; Soluble na alkali hydroxide ngwọta. Usoro njirimara bụ A: hydrochloric acid reflux hydrolysis ka quercetin, onye ebe agbaze ya bụ 312 ℃B: mmiri ozuzo na-acha uhie uhie cuprous oxide. C: Ịgbakwunye sodium hydroxide ngwọta bụ oroma odo D: ethanol ngwọta na ferric chloride ngwọta bụ agba aja aja E: ethanol ngwọta na hydrochloric acid na magnesium nwayọọ nwayọọ na-acha ọbara ọbara ọdịnaya: ≥95.0% (UV) (site na akọrọ ngwaahịa)

Mbelata arọ akọrọ: 5.5% ~ 9.0%

Ihe fọdụrụ na-ere ọkụ ≤0.5%

Chlorophyll ≤0.004%

Agba uhie ≤0.004%

Ihe metụtara quercetin ≤5.0%(UV)

Ngụkọta ọnụ ọgụgụ nke nje aerobic ≤103cfu/g

Ngụkọta ọnụ ọgụgụ ebu na yist ≤102cfu/g

Agaghị achọpụta Escherichia coli /g

Ọnọdụ nchekwa Chekwaa n'ime akpa ikuku na-adịghị na ìhè.

2. Rutoside Trihydrate EP 9.0: odo ma ọ bụ odo-acha akwụkwọ ndụ ntụ ntụ. Ihe fọrọ nke nta ka ọ bụrụ ihe a na-adịghị ahụkebe na mmiri, soluble na methanol, ntakịrị soluble na ethanol (96%), ọ fọrọ nke nta ka ọ ghara ịsolu na methylene chloride. Soluble na hydroxide ngwọta. Usoro njirimara bụ dị ka ndị a: A: Ntinye kachasị na 257nm na 358nm, na ọnụọgụ absorption kacha na 358nm bụ 305 ~ 330. B: Usoro ntinye nke infrared kwesịrị ịdị na nke ngwaahịa ntụaka C: ntụpọ nke otu agba na nha ga-apụta n'ọnọdụ kwekọrọ na chromatogram nke ngwaahịa ntụaka D: ngwọta ethanol na hydrochloric acid na zinc ga-egosi ọbara ọbara.

Ọdịnaya 95.0% ~ 101.0% (site na ngwaahịa akọrọ) (titration)

Mmiri 7.5% ~ 9.5% (Cartesian)

Ihe fọdụrụ na-ere ọkụ ≤0.1%

Uru nnabata ọkụ kachasị nke adịghị ọcha anya na 450nm ruo 800nm ​​agaghị abụ ihe karịrị 0.10

Ihe na-adịghị edozi na methanol ≤3.0%

Ihe metụtara isoquercetin ≤2.0%, kaempferol-3-rutin ≤2.0%, quercetin ≤2.0%, ngụkọta adịghị ọcha ≤4.0%(HPLC)

Ngụkọta ọnụọgụ nje bacteria aerobic ≤104cfu/g

Ngụkọta ọnụ ọgụgụ ebu na yist ≤102cfu/g

Bile gram-adịghị mma nje bacteria ≤102cfu/g

Agaghị achọpụta Escherichia coli /g

Enwere ike ghara ịchọta Salmonella / 25g

Ọnọdụ nchekwa na-ewepụ ìhè

3. Rutin USP43: Usoro njirimara bụ A: ntinye kachasị na 257nm na 358nm, na ọnụọgụ absorption kachasị na 358nm bụ 305 ~ 33. B: Ụdị ihe nrịbama nke infrared kwesịrị ịdị na chromatogram nke ngwaahịa ntụaka. C: Oge njide nke elu chromatogram kwesịrị ịdị na nke ngwaahịa ntụaka

Ọdịnaya 95.0% ~ 101.0% (site na ngwaahịa akọrọ) (titration)

Mmiri 7.5% ~ 9.5% (Cartesian)

Ihe fọdụrụ na-ere ọkụ ≤0.1%

Uru nnabata ọkụ kachasị nke adịghị ọcha anya na 450nm ruo 800nm ​​agaghị abụ ihe karịrị 0.10

Ihe na-adịghị edozi na methanol ≤3.0%

Ihe ndị metụtara isoquercetin ≤2.0%, kaempferol-3-rutin ≤2.0%, quercetin ≤2.0%, mono-iche iche ≤1.0%, ngụkọta adịghị ọcha ≤4.0% (HPLC)

Ngụkọta ọnụọgụ nje bacteria aerobic ≤104cfu/g

Ngụkọta ọnụ ọgụgụ ebu na yist ≤103cfu/g

Agaghị achọpụta Escherichia coli /10g

A gaghị achọpụta Salmonella / 10g

A kpuchiri ọnọdụ nchekwa ma zere ìhè.

4. Ọkọlọtọ ozi WS1-49(B) -89 nke Rutinum: odo ma ọ bụ odo-acha akwụkwọ ndụ ntụ ntụ, ma ọ bụ ezigbo kristal acicular; Enweghị isi, enweghị ụtọ; Agba agba ọchịchịrị na ikuku; Na-ekpo ọkụ na 185 ~ 192 ℃ ka ọ bụrụ gel agba aja aja. Obere soluble na ethanol na-esi esi, na-agbaze ntakịrị n'ime mmiri esi mmiri, ọ dị ntakịrị soluble na mmiri oyi, enweghị ike ime na trichloromethane na ether; Soluble na alkali hydroxide ngwọta. Usoro njirimara bụ: A: red cuprous oxide precipitate. B: Usoro nnabata infrared kwesịrị ịdị na nke ihe nchịkwa. C: A na-achọta nnabata kachasị na ogologo ebili mmiri nke 259 ± 1nm na 362.5 ± 1nm.

Ọdịnaya ≥93.0%(UV)(site na ngwaahịa akọrọ)

Mbelata arọ akọrọ 5.5% ~ 9.0%

Ihe fọdụrụ na-ere ọkụ ≤0.3%

Ihe na-adịghị edozi na methanol ≤2.5% (ihe na-adịghị edozi na ethanol)

Ihe emetụtara quercetin ≤4.0%(okpukpu dị mkpa)

Ngụkọta ọnụ ọgụgụ nke nje aerobic ≤103cfu/g

Ngụkọta ọnụ ọgụgụ ebu na yist ≤102cfu/g

Agaghị achọpụta Escherichia coli /g

A gaghị achọpụta Salmonella / g

A kpuchiri ọnọdụ nchekwa ma zere ìhè.

Mmetụta ọgwụ:

Ihe omume radical free

Oxygen molecules na-ebelata n'ụdị nke otu electrons na cell metabolism, na O ions eme site mbelata nke oxygen molekul n'ụdị otu eletrọn ga-emepụta H2O2 na ukwuu nsi ·OH free radicals n'ime ahụ, si otú na-emetụta akpụkpọ. ire ụtọ na ọbụna mee ngwangwa akpụkpọ ịka nká. Ọzọkwa, ịgbakwụnye rutin na ngwaahịa ahụ nwere ike iwepụ ụdị oxygen na-emeghachi omume nke mkpụrụ ndụ na-emepụta. Rutin bụ ngwakọta nke flavonoid, nke bụ antioxidant siri ike maka ịchafụ free radicals. Ọ nwere ike ịkwụsị mmeghachi omume yinye nke free radicals, gbochie peroxidation nke polyunsaturated fatty acids na biofilms, wepụ ngwaahịa peroxidation lipid, chebe iguzosi ike n'ezi ihe nke biofilms na akụkụ subcellular, ma na-arụ ọrụ dị mkpa na ahụ. [2]

Anti-lipid peroxidation

Lipid peroxidation na-ezo aka na usoro oxidation usoro nke ụdị oxygen na-emeghachi omume na-awakpo acid fatty polyunsaturated na biofilms. Zhu Jianlin et al. kpebisiri ike ma nyochaa ọrụ SOD na oke, ọdịnaya nke ngwaahịa mDA nke lipid peroxidation free, yana ọdịnaya nke Lipofuscin dị na imeju buru ibu, wee chọpụta na rutin nwere mmetụta mgbochi na lipid peroxidation n'ime oke awụsara, ma nwee ike igbochi mbelata ikike antioxidant. nke usoro antioxidant na oke mgbe a chụsịrị ya. Rutin nwere ike iguzogide mbelata nke ikike antioxidant kpatara mbelata nke estrogen endogenous ma nwee mmetụta antioxidant. Lipoproteins dị elu (HDL) nwere mmetụta antiatherosclerotic. Otú ọ dị, HDL, dị ka obere njupụta lipoprotein (LDL) na obere njupụta lipoprotein (VLDL), nwekwara ike ịbụ oxidized na gbanwee na vitro. Ozugbo HDL oxidized na gbanwee na Ox-HDL, ọ na-enwe mmetụta nke atherosclerosis. Meng Fang et al. nyochara mmetụta rutin na mgbanwe HDL oxidative site na Cu2+ na-emegharị oxidative mgbanwe na vitro. Mkpebi Rutin nwere ike igbochi mgbanwe oxidative nke HDL. [2]

Mmetụta mgbochi nke ihe na-arụ ọrụ platelet

Usoro nke ọtụtụ ọrịa obi na ọrịa ụbụrụ, dị ka thrombosis, atherosclerosis, mmeghachi omume mkpali na ischemia-reperfusion free radical , nwere njikọ chiri anya na mgbasa ozi nke plateletactivatingfactor (PAF). Ya mere, imegide mmetụta nke PAF bụ ụzọ dị mkpa iji belata ọrịa obi na-arịa ọrịa ischemic na cerebrovascular. Nnwale gosipụtara na rutin nwere ike imegide njikọ PAF na oke bekee na-anabata ndị na-anabata platelet, na-egbochi nnabata platelet nke PAf na oke bekee yana mmụba nke mkpokọta Ca2 + n'efu na PMN, na-atụ aro na usoro nke anti-PAF nke rutin bụ. iji gbochie ịgbalite onye na-anabata PAF, wee gbochie mmeghachi omume nke PAF kpaliri, ka o wee rụọ ọrụ na nchekwa obi obi. Nsonaazụ gosiri na rutin bụ onye na-emegide ndị na-anabata PAF. [2]

Anti-nnukwu pancreatitis

Rutin nwere ike igbochi hypocalcemia nke ọma ma belata mkpokọta Ca2 + na anụ ahụ pancreatic. Achọpụtara na rutin nwere ike ịbawanye ọdịnaya nke phospholipase A2 (PLA2) na anụ ahụ pancreatic nke oke, na-atụ aro na rutin nwere ike igbochi mwepụta na ịgbalite PLA2 na anụ ahụ pancreatic. Rutin nwere ike igbochi ọnọdụ hypocalcemia nke ọma na oke AP, ikekwe site na igbochi nnabata Ca2 + na ibelata ibufe Ca2 + na sel anụ ahụ pancreatic, si otú ahụ belata mmebi pathophysiological na AP. [2]

Ntuziaka: https://mp.weixin.qq.com

https://xueshu.baidu.com/userenter/paper

Maka rutin, biko kpọtụrụ anyị. Anyị na-eche gị ebe a oge ọ bụla.