Akpụkpọ na mkpụrụ nke mkpụrụ vaịn na mkpụrụ osisi beri nwere resveratrol, nke na-eme ka mmanya uhie baa ọgaranya na ngwakọta a. Nnyocha na-egosi na ọ nwere nnukwu uru ahụike, mana ịkwesịrị ịmatakwu gbasara ego ole ị ga-aṅụ.
Ọ bụrụ na ị nụla na mmanya uhie na-enyere aka belata cholesterol, mgbe ahụ ị nụla maka resveratrol, ihe mejupụtara osisi a na-ejikarị eme mmanya uhie.
Ma e wezụga ịbụ akụkụ bara uru nke mmanya uhie na nri ndị ọzọ, resveratrol nwekwara ike ịba uru ahụike.
N'eziokwu, ihe mgbakwunye resveratrol nwere ọtụtụ uru ahụike dị egwu, gụnyere ichebe ọrụ ụbụrụ na ibelata ọbara mgbali elu (1, 2, 3, 4).
Isiokwu a na-akọwa ihe ịkwesịrị ịma gbasara resveratrol, tinyere uru asaa kachasị elu o nwere ike inweta n'ahụike.
Resveratrol bụ ihe ọkụkụ nke na-arụ ọrụ dị ka ihe na-egbochi ọrịa. Isi ihe oriri gụnyere mmanya uhie, mkpụrụ vaịn, ụfọdụ mkpụrụ osisi, na ahụekere (5, 6).
Ihe mejupụtara ya na-adịkarị n'ime akpụkpọ na mkpụrụ nke mkpụrụ vaịn na mkpụrụ osisi. Akụkụ mkpụrụ vaịn ndị a na-etinye aka na ịgba mmanya uhie, ya mere ha nwere oke resveratrol (5, 7).
Agbanyeghị, e meela ọtụtụ ọmụmụ resveratrol n'ime anụmanụ na n'ime tube nnwale site na iji nnukwu ihe mejupụtara a (5, 8).
N'ime nnyocha ole na ole e mere n'ime ụmụ mmadụ, ọtụtụ lekwasịrị anya n'ụdị ihe mejupụtara ya, nke a na-ahụ n'ọtụtụ dị elu karịa nke e si na nri nweta (5).
Resveratrol bụ ihe na-egbochi ọrịa nke a na-ahụ n'ime mmanya uhie, mkpụrụ osisi na ahụekere. Ọtụtụ nnyocha mmadụ mere egosila na e nwere ihe mgbakwunye nwere nnukwu resveratrol.
N'ihi ihe ndị na-egbochi ya, resveratrol nwere ike ịbụ ihe mgbakwunye na-ekwe nkwa maka ibelata ọbara mgbali elu (9).
Nnyocha nke afọ 2015 kwubiri na oke dose nwere ike inye aka belata nrụgide dị na mgbidi akwara mgbe obi na-akụ (3).
A na-akpọ nrụgide a ọbara mgbali systolic ma ọ na-apụta dị ka ọnụọgụ dị elu na ọgụgụ ọbara mgbali.
Ọbara mgbali elu na-abawanye ka afọ na-aga n'ihu n'ihi atherosclerosis. Mgbe ọ dị elu, ọ na-akpata ọrịa obi.
Resveratrol nwere ike ime ka ọbara gbakee site n'inyere aka mepụta nitric oxide karịa, nke na-eme ka arịa ọbara zuru ike (10, 11).
Agbanyeghị, ndị dere nnyocha ahụ kwuru na ọ dị mkpa ka e mee nnyocha ndị ọzọ iji nye ndụmọdụ kpọmkwem gbasara oke resveratrol maka mmetụta kachasị na ọbara mgbali elu.
Ọtụtụ nnyocha anụmanụ egosila na mgbakwunye resveratrol nwere ike ịgbanwe lipids dị n'ọbara n'ụzọ dị mma (12, 13).
N'ime nnyocha e mere n'afọ 2016, e nyere òké nri nwere protein na abụba polyunsaturated nke e tinyere resveratrol.
Ndị nchọpụta ahụ chọpụtara na nkezi ọkwa cholesterol na ibu ahụ nke òké ahụ belatara, ebe ọkwa "ezigbo" cholesterol HDL mụbara (13).
O yiri ka Resveratrol na-emetụta ọkwa cholesterol site na ibelata ọrụ nke enzymes ndị na-achịkwa mmepụta cholesterol (13).
Dịka ihe na-egbochi ọrịa, ọ na-ebelatakwa oxidation nke cholesterol LDL "ọjọọ". Oxidation nke LDL na-eduga n'ịmepụta plaque na mgbidi akwara (9, 14).
Mgbe ọnwa isii nke ọgwụgwọ gasịrị, ndị sonyere na-aṅụ ihe ọṅụṅụ mkpụrụ vaịn na-enweghị mkpokọta ma ọ bụ placebo nwetara mbelata 4.5% na LDL na mbelata 20% na LDL oxidized (15).
Ihe mgbakwunye Resveratrol nwere ike ime ka ọkwa lipid dị n'ọbara dịkwuo mma n'ime anụmanụ. Ebe ọ bụ na ha na-egbochi oxidation, ha na-ebelatakwa oxidation nke LDL cholesterol.
Ike nke ihe mejupụtara ahụ iji mee ka ndụ ihe dị ndụ dị iche iche dịkwuo ogologo aghọwo akụkụ dị mkpa nke nyocha (16).
E nwere ihe akaebe na resveratrol na-eme ka ụfọdụ mkpụrụ ndụ ihe nketa rụọ ọrụ, si otú a na-egbochi ọrịa ndị na-akpata ịka nká (17).
Nke a na-arụ ọrụ n'otu ụzọ ahụ na mmachi kalori, nke egosila na ọ ga-ekwe omume ịbawanye ndụ site na ịgbanwe ụzọ e si egosipụta mkpụrụ ndụ ihe nketa (18, 19).
Nnyocha nke ọmụmụ ndị e mere n'ihe gbasara njikọ a chọpụtara na resveratrol gbatịkwuru ndụ mmadụ 60% nke ihe ndị dị ndụ e nyochara, mana mmetụta ya kacha pụta ìhè n'ihe ndị dị ndụ na-anaghị ejikọta mmadụ na ha, dịka ikpuru na azụ (20).
Nnyocha anụmanụ egosila na ihe mgbakwunye resveratrol nwere ike ịgbatị ndụ mmadụ. Agbanyeghị, o doro anya ma ha ga-enwe mmetụta yiri nke ahụ n'ahụ mmadụ.
Ọtụtụ nnyocha egosila na ịṅụ mmanya uhie nwere ike inye aka belata mbelata uche nke afọ (21, 22, 23, 24).
O yiri ka ọ na-egbochi iberibe protein a na-akpọ amyloid beta, nke dị oke mkpa n'ịmepụta ihe ndị e ji mara ọrịa Alzheimer (21, 25).
Ọ bụ ezie na nnyocha a na-atọ ụtọ, ndị ọkà mmụta sayensị ka nwere ajụjụ gbasara ikike ahụ nwere iji resveratrol mgbakwunye, na-ebelata ojiji ya ozugbo dị ka ihe mgbakwunye nchekwa ụbụrụ (1, 2).
Resveratrol bụ ihe na-egbochi mbufụt na ihe na-egbochi ọrịa nke nwere ike ichebe mkpụrụ ndụ ụbụrụ pụọ na mmebi.
Uru ndị a gụnyere ime ka mmetụta insulin dịkwuo mma na igbochi nsogbu ọrịa shuga (26, 27, 28, 29).
Otu nkọwa maka otu resveratrol si arụ ọrụ bụ na ọ nwere ike igbochi enzyme ịtụgharị glucose ka ọ bụrụ sorbitol, mmanya shuga.
Mgbe oke sorbitol gbakọtara n'ahụ ndị nwere ọrịa shuga, ọ nwere ike ibute nrụgide oxidative nke na-emebi mkpụrụ ndụ (30, 31).
Resveratrol nwere ike ịbara ndị ọrịa shuga uru karịa ndị na-abụghị ndị ọrịa shuga. N'otu nnyocha anụmanụ, a chọpụtara na mmanya uhie na resveratrol bụ ihe ndị na-egbochi ọrịa shuga ike karịa òké ndị na-enweghị ọrịa shuga (32).
Ndị nchọpụta na-ekwu na enwere ike iji ihe mejupụtara ya gwọọ ọrịa shuga na nsogbu ya n'ọdịnihu, mana ọ dị mkpa ka e mee nnyocha ndị ọzọ.
Resveratrol na-enyere òké aka ime ka mmetụta insulin dịkwuo mma ma lụso nsogbu ọrịa shuga ọgụ. N'ọdịnihu, ndị ọrịa nwere ọrịa shuga nwekwara ike irite uru site na ọgwụgwọ resveratrol.
A na-amụ ihe mgbakwunye ahịhịa dị ka ụzọ isi gwọọ ma gbochie mgbu nkwonkwo. Mgbe a na-aṅụ resveratrol dị ka mgbakwunye, ọ nwere ike inye aka chebe cartilage ka ọ ghara imebi (33, 34).
Otu nnyocha gbara resveratrol n'ime nkwonkwo ikpere nke oke bekee arthritic ma chọpụta na oke bekee ndị a enweghị mmebi cartilage dị ukwuu (34).
Nnyocha ndị ọzọ e mere na tube na anụmanụ egosila na ihe a nwere ike ibelata mbufụt ma gbochie mmebi nkwonkwo (33, 35, 36, 37).
A mụọla Resveratrol maka ikike ya igbochi na ịgwọ ọrịa kansa, ọkachasị na tube nnwale. Agbanyeghị, a gwakọtara nsonaazụ ya (30, 38, 39).
A gosila na ọ na-alụso ọtụtụ mkpụrụ ndụ kansa ọgụ n'ọmụmụ anụmanụ na tube ule, gụnyere kansa afọ, eriri afọ, akpụkpọ ahụ, ara, na prostate (40, 41, 42, 43, 44).
Agbanyeghị, ebe ọ bụ na a na-eme nnyocha ndị a ruo ugbu a n'ime tube nnwale na n'ime anụmanụ, ọ dị mkpa ka e mee nnyocha ndị ọzọ iji ghọta ma enwere ike iji ihe mejupụtara a gwọọ ọrịa kansa n'ime mmadụ na otu esi agwọ ya.
Nnyocha e mere na ihe mgbakwunye resveratrol ahụghị ihe egwu dị ukwuu ọ bụla. O yiri ka ndị nwere ahụike na-anabata ha nke ọma (47).
Agbanyeghị, ekwesịrị ịmara na ugbu a enweghị ndụmọdụ zuru oke gbasara ego ole resveratrol mmadụ kwesịrị iji nweta uru ahụike.
E nwekwara ụfọdụ ịdọ aka ná ntị, karịsịa gbasara otu resveratrol si emekọrịta ihe na ọgwụ ndị ọzọ.
Ebe ọ bụ na egosila na oke ọgwụ na-egbochi mkpụkọ ọbara n'ime ọkpọkọ nnwale, ha nwere ike ịbawanye ọbara ọgbụgba ma ọ bụ mmerụ ahụ mgbe ejiri ọgwụ mgbochi ọbara dị ka heparin ma ọ bụ warfarin, ma ọ bụ ụfọdụ ọgwụ mgbu (48, 49).
Resveratrol na-egbochikwa enzymes ndị na-enyere aka iwepụ ụfọdụ ihe ndị dị n'ahụ. Nke a pụtara na ụfọdụ ọgwụ nwere ike iru ọkwa dị ize ndụ. Ndị a gụnyere ụfọdụ ọgwụ ndị na-ebelata ọbara mgbali elu, ọgwụ mgbochi nchekasị, na ọgwụ mgbochi ahụ ike (50).
Ọ bụrụ na ị na-aṅụ ọgwụ ugbu a, ị nwere ike ịchọ ịgwa dọkịta gị okwu tupu ị na-aṅụ resveratrol.