Ahụ gị na-eji ya emepụta serotonin, onye ozi kemịkalụ na-eziga akara n'etiti mkpụrụ ndụ akwara.
Ejikọtala serotonin dị ala na ịda mbà n'obi, nchekasị, nsogbu ụra, ịba ụba ibu, na nsogbu ahụike ndị ọzọ (1, 2).
Mbelata ibu na-abawanye mmepụta nke homonụ na-akpata agụụ. Mmetụta a nke agụụ na-adịgide adịgide nwere ike ime ka ibu ibu ghara ịdịgide ogologo oge (3, 4, 5).
5-HTP nwere ike igbochi homonụ ndị a na-akpata agụụ na-egbochi agụụ ma nyere gị aka ifelata (6).
N'otu ọmụmụ ihe, e kenyere ndị ọrịa 20 na-arịa ọrịa shuga na-enweghị usoro ịnata 5-HTP ma ọ bụ placebo maka izu abụọ. Nsonaazụ gosiri na ndị natara 5-HTP riri ihe dị ka calorie 435 ole na ole kwa ụbọchị ma e jiri ya tụnyere placebo otu (7).
Kedu ihe ọzọ, 5-HTP na-egbochi oriri carbohydrate, nke jikọtara ya na njikwa glycemic ka mma (7).
Ọtụtụ nnyocha ndị ọzọ egosiwokwa na 5-HTP na-abawanye satiety ma na-akwalite oke ibu na oke ibu ma ọ bụ ndị buru ibu (8, 9, 10, 11).
Na mgbakwunye, ọmụmụ anụmanụ egosila na 5-HTP nwere ike ibelata oke oriri n'ihi nrụgide ma ọ bụ ịda mbà n'obi (12, 13).
5-HTP nwere ike ịdị irè n'ịba ụba satiety, nke nwere ike inyere gị aka iri obere nri ma felata.
Ọ bụ ezie na a maghị kpọmkwem ihe kpatara ịda mbà n'obi, ụfọdụ ndị nchọpụta kwenyere na enweghị ahaghị nhata nke serotonin nwere ike imetụta ọnọdụ gị, na-eduga na ịda mbà n'obi (14, 15).
N'ezie, ọtụtụ obere nnyocha egosiwo na 5-HTP nwere ike ibelata mgbaàmà nke ịda mbà n'obi. Otú ọ dị, abụọ n'ime ha ejighị placebo maka ntụnyere, nke kpaara uru nke nsonaazụ ha (16, 17, 18, 19).
Otú ọ dị, ọtụtụ nchọpụta egosiwo na 5-HTP nwere mmetụta dị ike nke na-eme ka ọ ghara ịda mbà mgbe ejiri ya na ihe ndị ọzọ ma ọ bụ antidepressants karịa mgbe ejiri ya naanị (17, 21, 22, 23).
Na mgbakwunye, ọtụtụ nyocha kwubiri na a chọrọ nyocha dị elu karịa tupu enwere ike ịkwado 5-HTP maka ọgwụgwọ ịda mbà n'obi (24, 25).
Ihe mgbakwunye 5-HTP na-abawanye ọkwa nke serotonin n'ime ahụ, nke nwere ike belata mgbaàmà nke ịda mbà n'obi, ọkachasị mgbe ejikọtara ya na antidepressants ndị ọzọ ma ọ bụ ọgwụ. Otú ọ dị, a chọkwuru nnyocha.
Mgbakwunye 5-HTP nwere ike imeziwanye ihe mgbaàmà nke fibromyalgia, nsogbu nke akwara na ọkpụkpụ na-egbu mgbu na adịghị ike n'ozuzu.
Enweghị ihe kpatara fibromyalgia ugbu a, mana ejikọtala ọkwa serotonin dị ala na ọnọdụ ahụ (26Trusted Source).
Nke a na-eduga ndị nchọpụta ikwere na ịkwalite ọkwa serotonin na mgbakwunye 5-HTP nwere ike ịbara ndị nwere fibromyalgia (27) uru.
N'ezie, ihe àmà mbụ na-egosi na 5-HTP nwere ike imeziwanye mgbaàmà nke fibromyalgia, gụnyere mgbu ahụ, nsogbu ụra, nchekasị, na ike ọgwụgwụ (28, 29, 30).
Agbanyeghị, emebeghị nyocha zuru oke iji nweta nkwubi okwu siri ike banyere ịdị irè nke 5-HTP iji meziwanye mgbaàmà fibromyalgia.
5-HTP na-abawanye ọkwa serotonin n'ime ahụ, nke nwere ike belata ụfọdụ mgbaàmà nke fibromyalgia. Otú ọ dị, a chọkwuru nnyocha.
A na-ekwu na 5-HTP na-enyere aka ịgwọ migraines, ụdị isi ọwụwa na-ejikọta ya na ọgbụgbọ ma ọ bụ ihe mgbagwoju anya.
Ọ bụ ezie na a na-arụrịta ụka kpọmkwem ihe kpatara ha, ụfọdụ ndị nchọpụta kwenyere na ọ bụ ọkwa serotonin dị ala (31, 32) kpatara ha.
Nnyocha mmadụ 124 tụnyere ikike nke 5-HTP na methylergometrine, ọgwụ migraine na-emekarị, iji gbochie isi ọwụwa migraine (33).
Otu nnyocha chọpụtara na ịṅụ 5-HTP kwa ụbọchị maka ọnwa isii gbochiri ma ọ bụ belata ọnụ ọgụgụ nke migraine ọgụ na 71% nke ndị sonyere (33).
N'ọmụmụ ihe ọzọ nke ụmụ akwụkwọ 48, 5-HTP belatara ugboro ugboro isi ọwụwa site na 70% ma e jiri ya tụnyere 11% na placebo otu (34).
N'otu aka ahụ, ọtụtụ nchọpụta ndị ọzọ egosila na 5-HTP nwere ike ịbụ ọgwụgwọ dị irè maka migraines (30, 35, 36).
Melatonin na-ekere òkè dị mkpa n'ịhazi ụra. Ọkwa ya na-amalite ibili n'abalị iji kwalite ụra ma daa n'ụtụtụ iji nyere gị aka iteta.
Ya mere, mgbakwunye 5-HTP nwere ike ịkwalite ụra site n'ịbawanye mmepụta nke melatonin n'ime ahụ.
Nnyocha mmadụ mere chọpụtara na nchikota 5-HTP na gamma-aminobutyric acid (GABA) belatara nke ukwuu oge ọ na-ewe iji hie ụra, ịba ụba ụra, na mma ụra dị mma (37).
GABA bụ ozi kemịkalụ na-akwalite ntụrụndụ. Ijikọta ya na 5-HTP nwere ike inwe mmetụta synergistic (37).
N'ezie, ọtụtụ ọmụmụ anụmanụ na ụmụ ahụhụ egosila na 5-HTP na-eme ka ụra dịkwuo mma ma dị mma karịa mgbe ejikọtara ya na GABA (38, 39).
Ọ bụ ezie na nsonaazụ ndị a na-ekwe nkwa, enweghị ọmụmụ mmadụ na-eme ka o sie ike ịkwado 5-HTP maka imeziwanye ụra ụra, karịsịa mgbe ejiri ya naanị ya.
Ụfọdụ ndị mmadụ nwere ike ịnwe ọgbụgbọ, afọ ọsịsa, ọgbụgbọ, na mgbu afọ mgbe ha na-ewere mgbakwunye 5-HTP. Mmetụta ndị a na-adabere na dose, nke pụtara na ha na-akawanye njọ ka dose ahụ na-abawanye (33).
Iji belata mmetụta ndị a, malite na dose nke 50-100 mg ugboro abụọ kwa ụbọchị ma gbasaa na dose kwesịrị ekwesị n'ime izu abụọ (40).
Ụfọdụ ọgwụ na-abawanye mmepụta nke serotonin. Ijikọta ọgwụ ndị a na 5-HTP nwere ike ibute ọkwa dị ize ndụ nke serotonin n'ime ahụ. A na-akpọ nke a ọrịa serotonin, ọnọdụ nwere ike igbu mmadụ (41).
Ọgwụ ndị nwere ike ịbawanye ọkwa serotonin n'ime ahụ gụnyere ụfọdụ antidepressants, ọgwụ ụkwara, ma ọ bụ ndị na-ebelata mgbu ọgwụ.
N'ihi na 5-HTP nwekwara ike ịkwalite ihi ụra, iji ya na ọgwụ ndị na-edozi ahụ dị ka Klonopin, Ativan, ma ọ bụ Ambien nwere ike ime ka ụra buru ibu.
N'ihi mmekọrịta ọjọọ na ọgwụ ndị ọzọ nwere ike ime, lelee dọkịta gị ma ọ bụ onye na-ere ọgwụ tupu ị nweta ihe mgbakwunye 5-HTP.
Mgbe ị na-azụ ahịa maka mgbakwunye, chọọ akara NSF ma ọ bụ USP nke na-egosi ogo dị elu. Ndị a bụ ụlọ ọrụ ndị ọzọ na-ekwe nkwa na mgbakwunye ndị ahụ nwere ihe ekwuru na labelụ na enweghị adịghị ọcha.
Ụfọdụ ndị mmadụ nwere ike nweta mmetụta dị n'akụkụ mgbe ị na-ewere mgbakwunye 5-HTP. Lelee dọkịta gị tupu ị were 5-HTP iji jide n'aka na ọ dị gị mma.
Ihe mgbakwunye ndị a dị iche na mgbakwunye L-tryptophan, nke nwekwara ike ịbawanye ọkwa serotonin (42).
L-tryptophan bụ amino acid dị mkpa dị na nri nwere protein dị ka mmiri ara ehi, anụ ọkụkọ, anụ, chickpeas, na soy.
N'aka nke ọzọ, 5-HTP adịghị ahụ na nri ma enwere ike itinye ya na nri gị site na mgbakwunye nri (43).
Ahụ gị na-atụgharị 5-HTP ka ọ bụrụ serotonin, ihe na-achịkwa agụụ, nghọta mgbu, na ụra.
Ọkwa serotonin dị elu nwere ike nweta ọtụtụ uru, dị ka ịbelata ibu arọ, ahụ efe pụọ na mgbaàmà ịda mbà n'obi na fibromyalgia, belata oge ọgụ migraine, na ụra ka mma.
Ejikọtala obere ihe mmetụta na 5-HTP, mana enwere ike ibelata ndị a site na ịmalite na obere doses wee jiri nwayọọ nwayọọ na-abawanye dose ahụ.
Nyere na 5-HTP nwere ike iji ọgwụ ụfọdụ na-emekọrịta ihe na-adịghị mma, lelee dọkịta gị ka ị hụ na ọ dị gị mma.
Ndị ọkachamara anyị na-enyocha ebe ahụike na ahụike mgbe niile ma na-emelite akụkọ anyị ka ozi ọhụrụ na-adị.
A na-ejikarị 5-HTP eme ihe dị ka mgbakwunye iji mee ka ọkwa serotonin dịkwuo elu. Ụbụrụ na-eji serotonin ahazi ọnọdụ, agụụ, na ọrụ ndị ọzọ dị mkpa. mana…
Kedu ka Xanax si agwọ ịda mbà n'obi? A na-ejikarị Xanax agwọ ọrịa nchegbu na ụjọ.